Endocrine Abstracts

Thyroid hormone (TH) plays an essential role in the proper development of the brain and peripheral tissues. Lack of sufficient TH results in abnormal development, including mental retardation. TH transporters are necessary for the intracellular availability of TH to have access to the deiodinases and nuclear receptors inside the cell. Different specific TH transporters are known to date including the monocarboxylate transporters 8 (MCT8) and 10 (MCT10), and the organic anion t...